Medically reviewed by Dr. Wladimir Lorentz, MD, board-certified pediatrician (Aventura/Miami, FL) — co-author of the published study — last reviewed July 16, 2026

The Clinical Study Behind Colic Calm

Most gripe waters ask parents to take their word for it. Colic Calm doesn’t have to — it was evaluated in a peer-reviewed clinical study, published in Global Pediatric Health and indexed on PubMed Central (PMC), the U.S. National Library of Medicine’s public database of biomedical research.

This page lays out exactly what the study did, what it found, and what its limits are — plainly, so you can decide for yourself what it means for your family.

The Study at a Glance

• 30 infants enrolled, ages 3 to 16 weeks, all diagnosed with infantile colic
• 21-day study period, with assessments at baseline, day 7, day 14, and a follow-up at day 21
• Published in Global Pediatric Health, a peer-reviewed journal, and indexed on PMC
• Primary measure: daily crying time, tracked against each infant’s own baseline
• Result: a significant reduction in daily crying time and flatulence within the first week, sustained through day 21, with no significant adverse effects reported

Read the published study on PubMed Central →

What the Researchers Measured

The study tracked several things over the three-week period:

• Daily inconsolable crying time, compared to baseline
• Frequency and severity of gastrointestinal symptoms (gas, discomfort)
• Sleep patterns
• Caregiver-reported tolerability
• Whether symptoms returned after the product was stopped

What the Study Found

Crying time and flatulence both decreased significantly within the first week of use. The improvement held through the full 21-day period, and the effect appeared to continue even after infants stopped using the product — rather than symptoms simply returning once a dose wore off. No significant adverse effects were reported during the study.

What This Study Doesn’t Claim

We think it’s just as important to be clear about what this research is not:

• This was an open-label study — caregivers and researchers knew which product infants were receiving. 
• Colic has multiple possible causes, and this study evaluated one product’s effect on symptoms — it isn’t a diagnosis tool or a substitute for talking to your pediatrician, especially if your baby’s symptoms are severe, unusual, or accompanied by fever, poor weight gain, or other warning signs.
  

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The information on this page is for educational purposes only and is not medical advice. Always consult your pediatrician with questions about your child’s health.

Frequently Asked Questions

Is Colic Calm backed by a clinical study?
Yes. Colic Calm was evaluated in a peer-reviewed clinical study published in Global Pediatric Health and indexed on PubMed Central, involving 30 infants over a 21-day period.

What did the Colic Calm clinical study find?
The study found a significant reduction in daily crying time and flatulence within the first week of use, with the improvement sustained through day 21, and no significant adverse effects reported.

Was the study peer-reviewed?
Yes — it was published in Global Pediatric Health, a peer-reviewed journal, and is indexed on PubMed Central (PMC), the U.S. National Library of Medicine’s database.

Is Colic Calm the only gripe water with a published clinical study?
Yes. Based on a review of the other leading gripe water brands (Wellements, Mommy’s Bliss, Little Remedies, and MaryRuth’s), Colic Calm is currently the only one with a published clinical study of the product itself. Other brands reference general research on individual ingredients (such as probiotics or chamomile) or point to decades of traditional use, but none has published a clinical study evaluating their specific formula.

Why We’re Sharing This

A lot of products in this category make broad claims without much to back them up. We’d rather show you the actual research, including its limits, so you can make an informed decision for your baby — not just take a marketing claim at face value.